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Chemical Structure : Kenpaullone
CAS No.: 142273-20-9
Catalog No.: PC-42965Not For Human Use, Lab Use Only.
Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM).
Kenpaullone shows less effect on other kinases, only c-Src, CK2, ERK1/2 (IC50=15-20 uM) with IC50s less than 30 uM.
Kenpaullone displays delayed cell cycle progression in treated cells; also is a potent inhibitor of GSK-3β (IC50=23 nM), activates Nanog expression in mouse fibroblasts transduced with a subset of reprogramming factors lacking Klf4, can replace Klf4 in the reprogramming of primary and secondary fibroblasts and NPCs.
| M.Wt | 327.1754 | |
| Formula | C16H11BrN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro- |
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1. Zaharevitz DW, et al. Cancer Res. 1999 Jun 1;59(11):2566-9.
2. Schultz C, et al. J Med Chem. 1999 Jul 29;42(15):2909-19.
3. Bain J, et al. Biochem J. 2003 Apr 1;371(Pt 1):199-204.
4. Lyssiotis CA, et al. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7.
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