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Chemical Structure : ON123300
CAS No.: 1357470-29-1
Catalog No.: PC-43121Not For Human Use, Lab Use Only.
Narazaciclib (ON123300) is a potent, multi-targeted kinase inhibitor with IC50 of 5, 3.9, 26, 26, 9.2 and 11 nM for ARK5, CDK4, PDGFRβ, FGFR1, RET and FYN, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Narazaciclib (ON123300) is a potent, multi-targeted kinase inhibitor with IC50 of 5, 3.9, 26, 26, 9.2 and 11 nM for ARK5, CDK4, PDGFRβ, FGFR1, RET and FYN, respectively.
Narazaciclib (ON123300) inhibits U87 glioma cell proliferation with IC50 3.4 uM, and reduces phosphorylation of Akt, yet it also unexpectedly induces Erk activation and prevents phosphorylation of C-Raf S259.
Narazaciclib (ON123300) suppresses phosphorylation of Akt as well as activation of Erk in brain tumors in vivo.
Narazaciclib (ON123300) also exhibits potent activity against mantle cell lymphomas both in vitro and in vivo, triggers apoptosis and inhibition of the Rb and PI3K/AKT pathways.
| M.Wt | 429.5175 | |
| Formula | C24H27N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidine-6-carbonitrile, 8-cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo- |
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1. Zhang X, et al. Mol Cancer Ther. 2014 May;13(5):1105-16.
2. Divakar SK, et al. Leukemia. 2016 Jan;30(1):86-93.
3. Perumal D, et al. Cancer Res. 2016 Mar 1;76(5):1225-36.
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