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Chemical Structure : Enitociclib
CAS No.: 1610358-56-9
Catalog No.: PC-63127Not For Human Use, Lab Use Only.
Enitociclib ((±)-BAY-1251152) is a potent, highly specific P-TEFb/CDK9 inhibitor with IC50 of 3 nM. displays> 50-fold selectivity against other CDKs.
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|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 100 mg | Get quote |
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Enitociclib ((±)-BAY-1251152) is a potent, highly specific P-TEFb/CDK9 inhibitor with IC50 of 3 nM.
BAY-1251152 exhibits ex vivo potency (MOLM-13 cells, IC50=29 nM) and enhanced selectivity against CDK2, permeability, solubility, and no efflux.
BAY-1251152 has demonstrated IC50 of 19.06, 16.57 and 74.64 nM against HeLa, SiHa and OVCAR-3 cells, respectively.
BAY-1251152 is the only selective CDK9 inhibitor currently undergoing clinical trialsagainst advanced malignancies (NHL and solid tumors; NCT02635672).
| M.Wt | 404.436 | |
| Formula | C19H18F2N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(+)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine |
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1. Ulrich T. Luecking, et al. Abstract 984: Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops. DOI: 10.1158/1538-7445.
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