Catalog No.: PC-35532Not For Human Use, Lab Use Only.
Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK.
Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK.
Compound 919278 does not inhibit the TNF-α-mediated nuclear translocation of p65 (RelA).
Compound 919278 prevents the accumulation of NIK, selectively inhibits the noncanonical NF-kB pathway.
Compound 919278 prevents the LTβR- and FN14-dependent expression of MAP3K14 (which encodes NIK) as well as NIK accumulation by reducing phosphorylation of the carboxyl-terminal domain of RNA polymerase II.
Compound 919278 reduces the binding of both CDK12 and its associated protein CCNK with IC50 of 30-60 nM, inhibits CDK12 cellular activity and reduces the phosphorylation of Ser2 on the RNA Pol II CTD.
Compound 919278 phenocopies the effect of CDK12 knockdown on DEGs.
