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Chemical Structure : Compound 919278
CAS No.: 2189366-77-4
Catalog No.: PC-35532Not For Human Use, Lab Use Only.
Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK.
Compound 919278 does not inhibit the TNF-α-mediated nuclear translocation of p65 (RelA).
Compound 919278 prevents the accumulation of NIK, selectively inhibits the noncanonical NF-kB pathway.
Compound 919278 prevents the LTβR- and FN14-dependent expression of MAP3K14 (which encodes NIK) as well as NIK accumulation by reducing phosphorylation of the carboxyl-terminal domain of RNA polymerase II.
Compound 919278 reduces the binding of both CDK12 and its associated protein CCNK with IC50 of 30-60 nM, inhibits CDK12 cellular activity and reduces the phosphorylation of Ser2 on the RNA Pol II CTD.
Compound 919278 phenocopies the effect of CDK12 knockdown on DEGs.
| M.Wt | 320.352 | |
| Formula | C18H16N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-N-(1H-benzo[d]imidazol-2-yl)-2-(1-oxoisoindolin-2-yl)propanamide |
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1. Henry KL, et al. Sci Signal. 2018 Jul 31;11(541). pii: eaam8216.
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