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PF-06873600

Chemical Structure : PF-06873600

CAS No.: 2185857-97-8

PF-06873600 (Ebvaciclib, PF3600, PF 06873600)

Catalog No.: PC-35969Not For Human Use, Lab Use Only.

PF-06873600 (Ebvaciclib, PF06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-06873600 (Ebvaciclib, PF06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.
PF-06873600 (Ebvaciclib) demonstrates potential antineoplastic activity, incerease apoptosis and inhibits umor cell proliferation.

Physicochemical Properties

M.Wt 471.524
Formula C20H27F2N5O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-

References

1. Freeman-Cook K, et al. Cancer Cell. 2021 Oct 11;39(10):1404-1421.e11.
2. Freeman-Cook KD, et al. J Med Chem. 2021 Jul 8;64(13):9056-9077.

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