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Chemical Structure : PF-06873600
CAS No.: 2185857-97-8
Catalog No.: PC-35969Not For Human Use, Lab Use Only.
PF-06873600 (Ebvaciclib, PF06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | Get quote |
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PF-06873600 (Ebvaciclib, PF06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.
PF-06873600 (Ebvaciclib) demonstrates potential antineoplastic activity, incerease apoptosis and inhibits umor cell proliferation.
| M.Wt | 471.524 | |
| Formula | C20H27F2N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]- |
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1. Freeman-Cook K, et al. Cancer Cell. 2021 Oct 11;39(10):1404-1421.e11.
2. Freeman-Cook KD, et al. J Med Chem. 2021 Jul 8;64(13):9056-9077.
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