BAY-320 (BAY320) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 680 nM.
BAY-320 displays modest cross reactivity with a panel of 222 kianses at 10 uM.
BAY-320 reduces T120 phosphorylation of histone H2A in intact cells, affects chromosome association of Shugoshin proteins and the chromosomal passenger complex (CPC), without abolishing global Aurora B function, impairs chromosome arm resolution with minor effects on mitotic progression or SAC function.
BAY-320 sensitizes cells to Paclitaxel, impairing both chromosome segregation and cell proliferation.
