Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Purvalanol A
Purvalanol A

Chemical Structure : Purvalanol A

CAS No.: 212844-53-6

Add to Favorites

Purvalanol A (NG-60, NG60)

Catalog No.: PC-45447Not For Human Use, Lab Use Only.

Purvalanol A (NG-60) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.

Packing Price Stock Quantity
5 mg $68 In stock
25 mg $128 In stock
50 mg $198 In stock
100 mg $328 In stock
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Purvalanol A (NG-60) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.
Purvalanol A (NG-60)also inhibits Saccharomyces cerevisiae Cdc28p (IC50=80 nM) and has no effect on PKC, Raf, CK1, CK2.

Physicochemical Properties

M.Wt 388.8944
Formula C19H25ClN6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-

References

1. Gray NS, et al. Science. 1998 Jul 24;281(5376):533-8.

2. Chadebech P, et al. Int J Cancer. 2000 Sep 15;87(6):779-86.

3. Obakan P, et al. Mol Biol Rep. 2014 Jan;41(1):145-54.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: