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Chemical Structure : Purvalanol A
CAS No.: 212844-53-6
Catalog No.: PC-45447Not For Human Use, Lab Use Only.
Purvalanol A (NG-60) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 250 mg | Get quote |
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Purvalanol A (NG-60) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.
Purvalanol A (NG-60)also inhibits Saccharomyces cerevisiae Cdc28p (IC50=80 nM) and has no effect on PKC, Raf, CK1, CK2.
| M.Wt | 388.8944 | |
| Formula | C19H25ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)- |
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1. Gray NS, et al. Science. 1998 Jul 24;281(5376):533-8.
2. Chadebech P, et al. Int J Cancer. 2000 Sep 15;87(6):779-86.
3. Obakan P, et al. Mol Biol Rep. 2014 Jan;41(1):145-54.
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