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TAME

Chemical Structure : TAME

CAS No.: 901-47-3

TAME (Tosyl-L-arginine methyl ester)

Catalog No.: PC-43435Not For Human Use, Lab Use Only.

TAME (Tosyl-L-arginine methyl ester) is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1).

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Biological Activity

TAME (Tosyl-L-arginine methyl ester) is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1).
TAME inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 uM.
TAME promotes Cdc20 autoubiquitination, blocks cyclin degradation in interphase extract.

Physicochemical Properties

M.Wt 342.4139
Formula C14H22N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Arginine, N2-[(4-methylphenyl)sulfonyl]-, methyl ester

References

1. Zhang S, et al. Nature. 2016 May 12;533(7602):260-264.

2. Zeng X, et al. Cancer Cell. 2010 Oct 19;18(4):382-95.

3. Zeng X, et al. Nat Chem Biol. 2012 Feb 26;8(4):383-92.

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