Catalog No.: PC-42578Not For Human Use, Lab Use Only.
Milciclib (PHA-848125) is a potent, selective, brain penetrant and orally available dual CDK and TRK inhibitor with IC50 of 45 and 53 nM for CDK2/cyclin A and TrkA, respectively.
Milciclib (PHA-848125) is a potent, selective, brain penetrant and orally available dual CDK and TRK inhibitor with IC50 of 45 and 53 nM for CDK2/cyclin A and TrkA, respectively.
PHA-848125 also is a potent pseudokinase ULK4 binder with Ki of 4.4 uM.
PHA-848125 shows cross-reactivity with other CDKs (CDK1/4/5/7), TrkB/C, Kit, Abl and PDGFR (IC50s<1 uM).
PHA-848125 inhibits cell proliferation of a wide panel of tumoral cell lines with submicromolar IC50.
PHA-848125 shows significant antitumor activity in various human xenografts.
