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SU-9516

Chemical Structure : SU-9516

CAS No.: 377090-84-1

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SU-9516 (SU9516;SU 9516)

Catalog No.: PC-45491Not For Human Use, Lab Use Only.

SU-9516 is a potent, selective CDK2 inhibitor with IC50 of 22 nM.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SU-9516 is a potent, selective CDK2 inhibitor with IC50 of 22 nM.
SU-9516 shows less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK.
SU-9516 decreases the phosphorylation of pRb, and increases caspase-3 activation.

Physicochemical Properties

M.Wt 241.2453
Formula C13H11N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)-

References

1. Lane ME, et al. Cancer Res. 2001 Aug 15;61(16):6170-7.

2. Gao N, et al. Mol Pharmacol. 2006 Aug;70(2):645-55.

3. Sarathy A, et al. Mol Ther. 2017 Apr 5. pii: S1525-0016(17)30121-1.

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