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Chemical Structure : SU-9516
CAS No.: 377090-84-1
Catalog No.: PC-45491Not For Human Use, Lab Use Only.
SU-9516 is a potent, selective CDK2 inhibitor with IC50 of 22 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SU-9516 is a potent, selective CDK2 inhibitor with IC50 of 22 nM.
SU-9516 shows less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK.
SU-9516 decreases the phosphorylation of pRb, and increases caspase-3 activation.
| M.Wt | 241.2453 | |
| Formula | C13H11N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)- |
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1. Lane ME, et al. Cancer Res. 2001 Aug 15;61(16):6170-7.
2. Gao N, et al. Mol Pharmacol. 2006 Aug;70(2):645-55.
3. Sarathy A, et al. Mol Ther. 2017 Apr 5. pii: S1525-0016(17)30121-1.
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