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Chemical Structure : R547
CAS No.: 741713-40-6
Catalog No.: PC-42067Not For Human Use, Lab Use Only.
R547 is a potent, selective and ATP-competitive CDK inhibitor with Ki of 1/3/1 nM for CDK1/2/4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | Get quote |
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R547 is a potent, selective and ATP-competitive CDK inhibitor with Ki of 1/3/1 nM for CDK1/2/4, respectively.
R547 has no activity against a large panel of serine/threonine and tyrosine kinases.
R547 inhibits the growth of various human tumor cell lines (HCT116 cell line IC50=80 nM), blocks G1 and G2 phases, induces apoptosis and reduces phosphorylation of Rb.
R547 demonstrates significant in vivo efficacy in the HCT116 human colorectal tumor xenograft model in nude mice.
| M.Wt | 441.4522 | |
| Formula | C18H21F2N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, [4-amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)- |
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1. Chu XJ, et al. J Med Chem. 2006 Nov 2;49(22):6549-60.
2. DePinto W, et al. Mol Cancer Ther. 2006 Nov;5(11):2644-58.
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