You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-NU-2058
NU-2058

Chemical Structure : NU-2058

CAS No.: 161058-83-9

NU-2058 (O6-cyclohexylmethyl guanine;NU2058;NU 2058)

Catalog No.: PC-45599Not For Human Use, Lab Use Only.

NU-2058 is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 5 uM and 12 uM respectively.

Packing Price Stock Quantity
10 mg $88 In stock
25 mg $158 In stock
50 mg $248 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NU-2058 is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 5 uM and 12 uM respectively.
NU-2058  inhibits human tumor cells with a mean GI50 of 13±7 uM.
NU-2058  reduces CDK2-mediated phosphorylation of pRb, E2F transcriptional activity and proliferatio in both anti-estrogen-sensitive and resistant cells.
NU-2058  also inhibits DNA topoisomerase II ATPase activity (IC50=300 uM).

Physicochemical Properties

M.Wt 247.2963
Formula C12H17N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL

Chemical Name/SMILES

9H-Purin-2-amine, 6-(cyclohexylmethoxy)-

References

1. Arris CE, et al. J Med Chem. 2000 Jul 27;43(15):2797-804.

2. Johnson N, et al. Br J Cancer. 2010 Jan 19;102(2):342-50.

3. Harrison LR, et al. Biochem Pharmacol. 2009 May 15;77(10):1586-92.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: