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Chemical Structure : NU-2058
CAS No.: 161058-83-9
Catalog No.: PC-45599Not For Human Use, Lab Use Only.
NU-2058 is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 5 uM and 12 uM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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NU-2058 is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 5 uM and 12 uM respectively.
NU-2058 inhibits human tumor cells with a mean GI50 of 13±7 uM.
NU-2058 reduces CDK2-mediated phosphorylation of pRb, E2F transcriptional activity and proliferatio in both anti-estrogen-sensitive and resistant cells.
NU-2058 also inhibits DNA topoisomerase II ATPase activity (IC50=300 uM).
| M.Wt | 247.2963 | |
| Formula | C12H17N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
9H-Purin-2-amine, 6-(cyclohexylmethoxy)- |
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1. Arris CE, et al. J Med Chem. 2000 Jul 27;43(15):2797-804.
2. Johnson N, et al. Br J Cancer. 2010 Jan 19;102(2):342-50.
3. Harrison LR, et al. Biochem Pharmacol. 2009 May 15;77(10):1586-92.
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