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Chemical Structure : M2I-1
CAS No.: 312271-03-7
Catalog No.: PC-42103Not For Human Use, Lab Use Only.
M2I-1 is the first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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M2I-1 is the first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20.
M2I-1 is equally potent in inhibiting the binding of F-Mbp1 to Mad2.
M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20, weakens the spindle assembly checkpoint (SAC) response.
| M.Wt | 404.4832 | |
| Formula | C19H24N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
4,6(1H,5H)-Pyrimidinedione, 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo- |
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1. Kastl J, et al. ACS Chem Biol. 2015 Jul 17;10(7):1661-6.
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