M2I-1 |CAS:312271-03-7 Probechem Biochemicals

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Chemical Structure : M2I-1

CAS No.: 312271-03-7

M2I-1 (Mad2 inhibitor 1)

Catalog No.: PC-42103Not For Human Use, Lab Use Only.

M2I-1 is the first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20.

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25 mg	$158	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

M2I-1 is the first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20.
M2I-1 is equally potent in inhibiting the binding of F-Mbp1 to Mad2.
M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20, weakens the spindle assembly checkpoint (SAC) response.

Physicochemical Properties

M.Wt	404.4832
Formula	C19H24N4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	4,6(1H,5H)-Pyrimidinedione, 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-

References

1. Kastl J, et al. ACS Chem Biol. 2015 Jul 17;10(7):1661-6.

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M2I-1 (Mad2 inhibitor 1)

Biological Activity

Physicochemical Properties

References

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