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M2I-1

Chemical Structure : M2I-1

CAS No.: 312271-03-7

M2I-1 (Mad2 inhibitor 1)

Catalog No.: PC-42103Not For Human Use, Lab Use Only.

M2I-1 is the first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20.

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Biological Activity

M2I-1 is the first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20.
M2I-1 is equally potent in inhibiting the binding of F-Mbp1 to Mad2.
M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20, weakens the spindle assembly checkpoint (SAC) response.

Physicochemical Properties

M.Wt 404.4832
Formula C19H24N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 32 mg/mL

Chemical Name/SMILES

4,6(1H,5H)-Pyrimidinedione, 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-

References

1. Kastl J, et al. ACS Chem Biol. 2015 Jul 17;10(7):1661-6.

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