Chemical Structure : KY-065
CAS No.:
1670224-50-6
KY-065
(KY065)
Catalog No.: PC-23612Not For Human Use, Lab Use Only.
KY-065 is a potent, selective and ATP-competitive CDK8/19 inhibitor with IC50 of 4.4/3.6 nM respectively, without affecting the activities of other CDK family members.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KY-065 is a potent, selective and ATP-competitive CDK8/19 inhibitor with IC50 of 4.4/3.6 nM respectively, without affecting the activities of other CDK family members.
KY-065 also does not markedly inhibit the kinase activities of 30 serine/threonine kinases through a single point inhibition assay.
KY-065 ameliorates the suppressive differentiation in chondrocytes of Fgfr3Ach mice.
KY-065 decreases STAT1Ser727 phosphorylation in chondrocytes of Fgfr3Ach mice, with no significant effect on the phosphorylation level of STAT1Tyr701.
KY-065 elongates the long bone and improves growth plate cytoarchitecture in Fgfr3Ach mice.
Physicochemical Properties
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M.Wt
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399.44
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Formula
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C22H25NO6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-acetyl-3-4-[2-(tetrahydropyran-4-yloxy)ethoxy]phenoxybenzamide
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References
1. Sadamori K, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Dec 12:167626.
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