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P162-0948

Chemical Structure : P162-0948

CAS No.: 1358201-44-1

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P162-0948

Catalog No.: PC-23694Not For Human Use, Lab Use Only.

P162-0948 is a potent, selective cyclin-dependent kinase 8 (CDK8) inhibitor with IC50 of 50.4 nM, disrupts TGF-β1-induced cell migration.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

P162-0948 is a potent, selective cyclin-dependent kinase 8 (CDK8) inhibitor with IC50 of 50.4 nM, disrupts TGF-β1-induced cell migration.
P162-0948 displays high selectivity over 60 different kinases, including the structurally closest CDK9.
P162-0948 (5 uM) exhibits cytotoxicity and migration inhibition in A549 cells.
P162-0948 suppresseS the expression of EMT proteins in human alveolar epithelial cells.
P162-0948 inhibits TGF-β1-induced p-Smad3 T179 and RNA polymerase II pS2/S5 in A549 cells.

Physicochemical Properties

M.Wt 362.36
Formula C20H15FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-fluorobenzyl)-2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide

References

1. Tony Eight Lin, et al. J Chem Inf Model. 2024 Dec 31. doi: 10.1021/acs.jcim.4c02011.

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