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Arcyriaflavin A

Chemical Structure : Arcyriaflavin A

CAS No.: 118458-54-1

Arcyriaflavin A

Catalog No.: PC-23981Not For Human Use, Lab Use Only.

Arcyriaflavin A is a potent inhibitor of the cyclin D1/CDK4 complex with IC50 of 140 nM, also inhibits CaMKII with IC50 of 25 nM, suppresses tumor growth, migration, and invasion of metastatic melanoma cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Arcyriaflavin A is a potent inhibitor of the cyclin D1/CDK4 complex with IC50 of 140 nM, also inhibits CaMKII with IC50 of 25 nM, suppresses tumor growth, migration, and invasion of metastatic melanoma cells.

Physicochemical Properties

M.Wt 325.33
Formula C20H11N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-

References

1. P A Horton, et al. Experientia. 1994 Sep 15;50(9):843-5.

2. Sanchez-Martinez C, et al. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3835-9.

3. Kim D, et al. Cancer Cell Int. 2025 Feb 13;25(1):42.

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