Catalog No.: PC-23502Not For Human Use, Lab Use Only.
BSJ-01-175 is a potent, selective dual CDK12/13 covalent inhibitor with IC50 of 156 nM (CDK12/CycK) and 282.6 nM（CDK3/CycK), targets cysteine Cys1039 on CDK12 (or Cys1017 on CDK13).
BSJ-01-175 is a potent, selective dual CDK12/13 covalent inhibitor with IC50 of 156 nM (CDK12/CycK) and 282.6 nM（CDK3/CycK), targets cysteine Cys1039 on CDK12 (or Cys1017 on CDK13). BSJ-01-175 specifically targets CDK12/13 and suppresses the transcription of BRAC1 and BRAC2. BSJ-01-175 exhibits antiproliferative activity of BSJ-01-175 in TC71 Ewing sarcoma cells with IC50 of 160 nM. BSJ-01-175 (10 mg/kg, IP qD) suppresses tumor growth of Ewing sarcoma in TC71 xenograft mouse model of Ewing sarcoma.
