| Cat. No. |
Product Name |
Information |
| PC-25402 |
TP-1287
CDK9 inhibitor
|
TP-1287 is a prodrug of Alvocidib (Flavopiridol, HMR-1275), is an orally active CDK9 inhibitor. |
| PC-25358 |
CIRc-004
Cyclin A/B RxL inhibitor
|
CIRc-004 is a potent, cell-permeable dual cyclin A/B RxL inhibitor with IC50 of 0.13 and <0.02 uM for cyclin A1-CDK2 and cyclin B-CDK1, does not inhibit cyclin E1-CDK2, inhibits cyclin A/B-RxL interactions and induces apoptosis in cancer cells with high E2F activity. |
| PC-24989 |
AU3-14
CDK4/6 inhibitor
|
Auceliciclib (AU3-14, Ulecaciclib AU-314) is a potent and selective, brain-penetrant CDK4/6 inhibitor with Ki values ranging from 0.2 to 3.3 nM. |
| PC-24915 |
AS3334366
CDK8/19 inhibitor, Foxp3 inducer
|
AS3334366 is a potent, selective orally active inhibitor of CDK8 and CDK19 with IC50 of 0.68 nM and 1.9 nM, respectively, AS3334366 is a potent Foxp3 inducer in Tconv cells with EC50 of 13.1 nM. |
| PC-24914 |
AS2863619
CDK8/19 inhibitor, Foxp3 inducer
|
AS2863619 is a potent, selective and orally active inhibitor of CDK8 and CDK19 with IC50 of 0.61 nM and 4.28 nM, respectively, AS2863619 is a potent Foxp3 inducer in Tconv cells with EC50 of 32.5 nM. |
| PC-24657 |
Bireociclib
CDK4/6 inhibitor
|
Bireociclib (XZP-3287) is a novel potent, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor with IC50 of 2.7/16 nM respectively. |
| PC-24530 |
Tagtociclib hydrate
CDK2 inhibitor
|
Tagtociclib hydrate (PF-07104091 hydrate, Tegtociclib hydrate) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers. |
| PC-24325 |
SNX631-6
CDK8/19 inhibitor
|
SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively. |
| PC-23995 |
BLU-222
CDK2 inhibitor
|
Cirtociclib (BLU-222) is a potent, highly selective, ATP-competitive CDK2 inhibitor with IC50 of 2.6 nM (CDK2/cyclinE1) with strong selectivity (>200-fold) over CDK family members (1/4/6/7/9). |
| PC-23694 |
P162-0948
CDK8 inhibitor
|
P162-0948 is a potent, selective cyclin-dependent kinase 8 (CDK8) inhibitor with IC50 of 50.4 nM, disrupts TGF-β1-induced cell migration. |
| PC-23612 |
KY-065
CDK8 inhibitor
|
KY-065 is a potent, selective and ATP-competitive CDK8/19 inhibitor with IC50 of 4.4/3.6 nM respectively, without affecting the activities of other CDK family members. |
| PC-23502 |
BSJ-01-175
CDK12/13 inhibitor
|
BSJ-01-175 is a potent, selective dual CDK12/13 covalent inhibitor with IC50 of 156 nM (CDK12/CycK) and 282.6 nM（CDK3/CycK), targets cysteine Cys1039 on CDK12 (or Cys1017 on CDK13). |
