| Cat. No. |
Product Name |
Information |
| PC-22380 |
CDK9 inhibitor VC-1
CDK9 inhibitor
|
CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5. |
| PC-21140 |
Cyclin K degrader DS17
cyclin K degarder
|
Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM. |
| PC-21088 |
LDC000067
CDK9 inhibitor
|
LDC000067 (LDC067) is a highly specific inhibitor of CDK9 with IC50 of 44 nM (CDK9-Cyclin T1), highly selective over other CDKs in the range of 55-fold (CDK2) to over 230-fold (CDK6 and CDK7). |
| PC-21051 |
SW394703
cyclin K degrader
|
SW394703 is a novel DDB1-dependent molecular glue degrader for cyclin K, SW394703 is toxic to HCT116 cells (IC50=1.2 uM). |
| PC-20880 |
CAF-382
CDKL5 inhibitor
|
CAF-382 (SGC-CAF382-1) is a potent, specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) with IC50 of 11 nM in NanoBRET assays, shows no activity against GSK3β. |
| PC-20566 |
Apcin-A
APC inhibitor, Cdc20 inhibitor
|
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor, interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. |
| PC-20345 |
Cdc25A inhibitor 7h
Cdc25A inhibitor
|
Cdc25A inhibitor 7h is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
| PC-20344 |
Cdc25A inhibitor 7g
Cdc25A inhibitor
|
Cdc25A inhibitor 7g is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
| PC-20316 |
LDC4297
CDK7 inhibitor
|
LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM). |
| PC-20219 |
CDK8 inhibitor 32
CDK8 inhibitor
|
CDK8 inhibitor 32 is a potent selective CDK8 inhibitor with IC50 of 1.5 nM, reduces phosphorylation of the known CDK8 substrate STAT1 in a manner identical to a CDK8 knockout clone. |
| PC-49792 |
SGC-CDKL5/GSK3-1
CDKL5/GSK3 inhibitor
|
CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively. |
| PC-49789 |
RGB-286147
CDK inhibitor
|
RGB-286147 (RGB 286147) is a proteome-wide CDK/CRK-specific kinase inhibitor with IC50 of 48 and 15 nM for CDK1/CycB and CDK2/CycE, respectively. |
