Chemical Structure : CDK17 inhibitor DU12
CAS No.:
2071661-14-6
CDK17 inhibitor DU12
Catalog No.: PC-26877Not For Human Use, Lab Use Only.
DU12 is a potent small molecule CDK17 inhibitor with IC50 of 0.76 uM against recombinant CDK17 kinase, inhibits the proliferation, colony formation, migration, and invasion of SKOV3 and A2780 ovarian cancer cells with IC50 of 2.83 uM and 2.65 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DU12 is a potent small molecule CDK17 inhibitor with IC50 of 0.76 uM against recombinant CDK17 kinase, inhibits the proliferation, colony formation, migration, and invasion of SKOV3 and A2780 ovarian cancer cells with IC50 of 2.83 uM and 2.65 uM.
DU12 significantly suppressed tumor growth and downregulated the expression of CDK17, SEMA6C, and PLXNA2 in tumor tissues.
DU12 downregulates the SEMA6C-Plexin A2 signaling pathway by targeting CDK17.
CDK17 promotes SEMA6C protein stability by suppressing its ubiquitin-dependent degradation.
DU12 markedly inhibits ovarian cancer growth in vivo and downregulates the CDK17-SEMA6C axis.
Physicochemical Properties
|
M.Wt
|
538.55
|
|
Formula
|
C32H26O8
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
5-hydroxy-2-(4-methoxy-3-(2-phenylacetoxy)phenyl)-4-oxochroman-7-yl 2-phenylacetate
|
References
1. Pan C, et al. Biochem Pharmacol. 2026 May 15:118069.
Contact Us
sales@probechem.com
