AS3334366

Chemical Structure : AS3334366

Catalog No.: PC-24915Not For Human Use, Lab Use Only.

AS3334366 is a potent, selective orally active inhibitor of CDK8 and CDK19 with IC50 of 0.68 nM and 1.9 nM, respectively, AS2863619 is a potent Foxp3 inducer in Tconv cells with EC50 of 13.1 nM.

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Biological Activity

AS3334366 is a potent, selective orally active inhibitor of CDK8 and CDK19 with IC50 of 0.68 nM and 1.9 nM, respectively, AS2863619 is a potent Foxp3 inducer in Tconv cells with EC50 of 13.1 nM.

Physicochemical Properties

M.Wt	415.50
Formula	C23H25N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-(1-(4-methoxyphenyl)piperidin-4-yl)-4-methyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine

References

1. Wang L, et al. Mater Today Bio. 2023 Jan 20;19:100557.

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AS3334366

Biological Activity

Physicochemical Properties

References

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