LL-K12-18

Chemical Structure : LL-K12-18

Catalog No.: PC-25971Not For Human Use, Lab Use Only.

LL-K12-18 is a potent, dual-site molecular glue degrader of cyclin K with DC50 of 0.38 nM in MDA-MB-231 cells, shows anti-proliferative effect against MDA-MB-231 cell with EC50 of 37 nM, enhances CDK12-DDB1 protein interaction.

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Biological Activity

Physicochemical Properties

M.Wt	559.50
Formula	C25H32Cl2N10O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(6-(((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-ethyl-9H-purin-2-yl)piperazin-1-yl)-2-(diethylamino)ethan-1-one

References

1. Zhang Z, et al. Nat Commun. 2024 Aug 1;15(1):6477.

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LL-K12-18

Biological Activity

Physicochemical Properties

References

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