A09-003

Chemical Structure : A09-003

Catalog No.: PC-26764Not For Human Use, Lab Use Only.

A09-003 is a potent inhibitor of cyclin-dependent kinase-9 (CDK9) with IC50 of 16 nM.

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Biological Activity

A09-003 is a potent inhibitor of cyclin-dependent kinase-9 (CDK9) with IC50 of 16 nM.
A09-003 exhibits high kinase selectivity against CDK2 (IC50=1205 nM).
A09-003 inhibits cell proliferation in various leukemia cell lines, is potent in MV4-11 and Molm-14 cells (IC50=0.48 and 0.86 uM), harboring the FLT-3 ITD mutation with a high expression profile of Mcl-1.
A09-003 reduces CDK-9 phosphorylation and reduced RNA polymerase II activity with decreased Mcl-1 expression.
Combining A09-003 with venetoclax induces apoptotic cell death in a synergistic manner.

Physicochemical Properties

M.Wt	374.49
Formula	C23H26N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(1,4-diazepan-1-yl)phenyl)-4-(2-methoxyphenyl)pyridin-2-amine

References

1. Sim KM, et al. Chem Biol Interact. 2023 Sep 1;382:110554.

2. Sim KM, et al. Discov Oncol. 2026 May 5. doi: 10.1007/s12672-026-04958-6.

A09-003

Biological Activity

Physicochemical Properties

References

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