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Cdc7 inhibitor 89S

Chemical Structure : Cdc7 inhibitor 89S

CAS No.: 1057097-72-9

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Cdc7 inhibitor 89S

Catalog No.: PC-27232Not For Human Use, Lab Use Only.

Cdc7 inhibitor 89S is a potent, ATP mimetic inhibitor of Cdc7 kinase with Ki of 0.5 nM, inhibits cell proliferation of different tumor cell lines with IC50 in submicromolar range, and exhibits in vivo tumor growth inhibition of 68% in the A2780 xenograft model.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Cdc7 inhibitor 89S is a potent, ATP mimetic inhibitor of Cdc7 kinase with Ki of 0.5 nM, inhibits cell proliferation of different tumor cell lines with IC50 in submicromolar range, and exhibits in vivo tumor growth inhibition of 68% in the A2780 xenograft model.

Physicochemical Properties

M.Wt 275.29
Formula C13H14FN5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoro-ethyl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

References

1. Maria Menichincheri, et al. J Med Chem. 2009 Jan 22;52(2):293-307.

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