Chemical Structure : CDK9 inhibitor HS34
CAS No.:
CDK9 inhibitor HS34
Catalog No.: PC-26367Not For Human Use, Lab Use Only.
CDK9 inhibitor HS34 is a potent, selective CDK9 inhibitor with IC50 of 1.4 nM (CDK9/CycT1), shows 250-fold selectivity over CDK2/CycA2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDK9 inhibitor HS34 is a potent, selective CDK9 inhibitor with IC50 of 1.4 nM (CDK9/CycT1), shows 250-fold selectivity over CDK2/CycA2.
HS34 shows potent and broad antiproliferative activity for MDA-MB-231 (GI50 = 0.22 μM) and 4T1 cells (GI50 = 0.53 μM).
HS34 (500 nM) inhibits CDK9 by 99.2%, demonstrating potent on-target activity.
HS34 effectively suppresses TNBC cell motility, inhibits the metastatic potential of TNBC cells.
HS34 suppresses RNAP II Ser2 phosphorylation, leading to the downregulation of short-lived survival and oncogenic proteins such as Mcl-1 and c-Myc, and consequently inducing apoptosis and blocking EMT-associated invasion.
HS34 (20 mg/kg, p.o.) demonstrated in vivo antitumor efficacy and mechanism-driven pharmacodynamics in TNBC models.
Physicochemical Properties
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M.Wt
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450.51
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Formula
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C25H27FN4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-N-(5-Fluoro-4-(4-((S)-2-methylpyrrolidin-1-yl)-2-oxo-2H-chromen-6-yl)pyridin-2-yl)piperidine-3-carboxamide
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References
1. Huang Y, et al. J Med Chem. 2026 Mar 11. doi: 10.1021/acs.jmedchem.5c03822.
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