Chemical Structure : CDK9 inhibitor C35
CAS No.:
3079792-32-5
CDK9 inhibitor C35
Catalog No.: PC-26368Not For Human Use, Lab Use Only.
CDK9 inhibitor C35 is a potent, selective and orally bioavailable CDK9 inhibitor with IC50 of 17.44 nM, shows 18-fold selectivity over CDK2.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDK9 inhibitor C35 is a potent, selective and orally bioavailable CDK9 inhibitor with IC50 of 17.44 nM, shows 18-fold selectivity over CDK2.
C35 exhibits noteworthy growth inhibition activities across three TNBC cell lines, with IC50 values ranging from 5 to 10 nM.
C35 effectively inhibited the phosphorylation on RPB1 CTD Ser2, a downstream target of CDK9 in TNBC cells.
C35 (10 mg/kg, p.o. daily) significantly suppressed the tumor progression in TNBC mouse models, significantly reduced the transcription level of the MCL1 gene in MDA-MB-231 xenografts and 4T1 allografts.
Physicochemical Properties
|
M.Wt
|
437.55
|
|
Formula
|
C23H31N7O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(4-(((8-isopropyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrazolo[1,5-a][1,3,5]triazin-4-yl)amino)methyl)phenyl)propionamide
|
References
1. Wang WJ, et al. J Med Chem. 2024 Jun 27;67(12):10035-10056.
Contact Us
sales@probechem.com
