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Chemical Structure : Atractylenolide II
CAS No.: 73069-14-4
Catalog No.: PC-21185Not For Human Use, Lab Use Only.
Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay).
Atractylenolide II is an inhibitor of the sn-1,2-DAG-PKCε pathway.
Atractylenolide II improves obesity-induced hyperlipidemia, hepatic steatosis, and insulin resistance, inhibits gluconeogenesis and promotes glycogen synthesis through the insulin-sensitive IRS1-PI3K-AKT pathway.
Atractylenolide II improves insulin resistance and hepatic steatosis in ob/ob or DIO mice by inhibiting gluconeogenesis and increasing hepatic glycogen synthesis.
Atractylenolide II reduces proteolysis of DGKQ but not of DGKA, DGKE, DGKZ, and ACTB.
| M.Wt | 232.32 | |
| Formula | C15H20O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4aS,8aR,9aS)-3,8a-dimethyl-5-methylene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one |
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1. Zu-Guo Zheng, et al. Cell Metab. 2023 Jan 3;35(1):101-117.e11.
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