Catalog No.: PC-21185Not For Human Use, Lab Use Only.
Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay).
Atractylenolide II (AT II, Asterolide) is a sesquiterpen enatural compound with anti-proliferative activity, also is a potent, specific allosteric activator of diacylglycerol kinase family member DGKQ (binding KD=1.75 uM, MST assay).
Atractylenolide II is an inhibitor of the sn-1,2-DAG-PKCε pathway.
Atractylenolide II improves obesity-induced hyperlipidemia, hepatic steatosis, and insulin resistance, inhibits gluconeogenesis and promotes glycogen synthesis through the insulin-sensitive IRS1-PI3K-AKT pathway.
Atractylenolide II improves insulin resistance and hepatic steatosis in ob/ob or DIO mice by inhibiting gluconeogenesis and increasing hepatic glycogen synthesis.
Atractylenolide II reduces proteolysis of DGKQ but not of DGKA, DGKE, DGKZ, and ACTB.
