Catalog No.: PC-63497Not For Human Use, Lab Use Only.
CU-3 (DGKα inhibitor CU-3) is a is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region.
CU-3 (DGKα inhibitor CU-3) is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region.
CU-3 competitively reduces the affinity of DGKα for ATP, but not diacylglycerol or phosphatidylserine, displays selectivity over other nine isozymes (IC50>7 uM).
CU-3 induces apoptosis in HepG2 hepatocellular carcinoma and HeLa cervical cancer cells while simultaneously enhancing the interleukin-2 production of Jurkat T cells.
