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Chemical Structure : BMS-684
CAS No.: 313552-29-3
Catalog No.: PC-21287Not For Human Use, Lab Use Only.
BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α (DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $148 | In stock | |
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α (DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases.
BMS-684 exhibits a dose-dependent potentiation of IL-2 production with EC5 of 5.43 uM.
BMS-684 does not induce a T cell response in the absence of TCR stimulation.
BMS-684 exhibits the hallmark phenotype of a candidate intracellular T cell checkpoint inhibitor.
BMS-684 induces translocation of DGKα to the membrane in T cells with EC50 of 0.54 uM in the YFP-DGKα high-content translocation assays.
| M.Wt | 454.53 | |
| Formula | C27H26N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-benzhydrylpiperazin-1-yl)-1-methyl-3-nitroquinolin-2(1H)-one |
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1. Wichroski M, et al. Sci Transl Med. 2023 Oct 25;15(719):eadh1892.
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