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BMS-332

Chemical Structure : BMS-332

CAS No.: 2407892-15-1

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BMS-332 (BMS332)

Catalog No.: PC-21532Not For Human Use, Lab Use Only.

BMS-332 (BMS332) is a potent, selective dual DGKα/ζ inhibitor with IC50 of 9/8 nM respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-332 (BMS332) is a potent, selective dual DGKα/ζ inhibitor with IC50 of 9/8 nM respectively.
BMS-332 displays >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ.
BMS-332 exhibits IC50 values of 5 nM and 1 nM in the YFP-DGKα and YFP-DGKζ high-content translocation assays, respectively.

Physicochemical Properties

M.Wt 499.57
Formula C29H27F2N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-[(2S,5R)-4-[Bis(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]-5,6-dihydro-5-methyl-6-oxo-1,5-naphthyridine-2-carbonitrile

References

1. Wichroski M, et al. Sci Transl Med. 2023;15(719):eadh1892.

2. L. Chupak, et al. ACS Med. Chem. Lett. 14, 929–935 (2023).

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