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Chemical Structure : BMS-502
CAS No.: 2407854-18-4
Catalog No.: PC-20914Not For Human Use, Lab Use Only.
BMS-502 (BMS502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | Get quote |
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BMS-502 (BMS502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively.
BMS-502 displays limited inhibitory activity toward the β, γ, and κ isoforms (IC50 values=0.68-4.6 uM).
BMS-502 demonstrates EC50 values of 280 and 340 nM in human whole-blood (hWB) measuring IFNγ production and phosphorylation of extracellular signal-regulated kinase (pERK), respectively.
BMS-502 inhibits proliferation of human effector CD8+ T-cells with EC50 of 65 nM, potentiates the immune response initiated by TcR activation.
BMS-502 (10 mpk, po) demonstrates dose-dependent immune stimulation in the mouse OT-1 model.
| M.Wt | 516.51 | |
| Formula | C27H22F2N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]-5,6-dihydro-5-methyl-7-nitro-6-oxo-1,5-naphthyridine-2-carbonitrile |
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1. Louis Chupak, et al. ACS Med Chem Lett. 2023 Jun 12;14(7):929-935.
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