Catalog No.: PC-20914Not For Human Use, Lab Use Only.
BMS-502 (BMS502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively.
BMS-502 (BMS502) is a potent, selective dual diacylglycerol kinases alpha and zeta (DGKα and DGKζ) inhibitor with IC5 of 4.6 anbd 2.1 nM, repspectively.
BMS-502 displays limited inhibitory activity toward the β, γ, and κ isoforms (IC50 values=0.68-4.6 uM).
BMS-502 demonstrates EC50 values of 280 and 340 nM in human whole-blood (hWB) measuring IFNγ production and phosphorylation of extracellular signal-regulated kinase (pERK), respectively.
BMS-502 inhibits proliferation of human effector CD8+ T-cells with EC50 of 65 nM, potentiates the immune response initiated by TcR activation.
BMS-502 (10 mpk, po) demonstrates dose-dependent immune stimulation in the mouse OT-1 model.
