Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Others-Diacylglycerol Kinase (DGK)-BMS-986408
BMS-986408

Chemical Structure : BMS-986408

CAS No.: 2618418-12-3

BMS-986408 (BMS 986408, BMS-408)

Catalog No.: PC-24873Not For Human Use, Lab Use Only.

BMS-986408 (BMS-408) is a potent, selective, DAG substrate competitive dual DGKα and DGKζ lipid kinase inhibitor with IC50 of 3 nM and 20 nM respectively, >100-fold selectivity for DGKα over DGKβ and DGKγ.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-986408 (BMS-408) is a potent, selective, DAG substrate competitive dual DGKα and DGKζ lipid kinase inhibitor with IC50 of 3 nM and 20 nM respectively, >100-fold selectivity for DGKα over DGKβ and DGKγ.
BMS-986408 inhibits DGKζ and DGKι with similar potency, shows no significant activity for Type II (DGKδ, DGKη, DGKκ), Type III (DGKε, or Type V (DGKθ) family members. BMS-986408 induces the translocation of both YFP-DGKα (EC50=0.026 µM) and YFP-DGKζ (EC50=0.008 µM) from cytoplasm to plasma membrane.
BMS-986408 also induces the degradation of both DGKα and DGKζ, which is ubiquitin and proteosome dependent.
BMS-986408 shows potent amplification of phospho-ERK in both CD4+ (EC50=0.008 µM) and CD8+ (EC50=0.012 µM) T cells and IL-2 production (Donor 1 EC50 0.019 µM; Donor 2 EC50 0.034 µM).
BMS-986408 amplified the antigen-specific activation of naïve mouse OT-1 CD8+ T cells by autologous BMDCs cross-presenting OVA, as measured by proliferation (EC50=0.015 µM) and IL-2 production (EC50=0.022 µM).
BMS-986408 also amplified the antigen specific killing of NY-ESO-1 antigen presenting SAOS-2 cells by human T cells transduced with NY-ESO-1 TCR (EC50=0.001 µM).
BMS-986408 binds to the accessory subdomain of the DGKα and DGKζ catalytic domain.
BMS-986408 broadly amplify T cell–mediated tumor immunity and invigorate both PD-1 immune checkpoint and CAR T-cell therapy.

Physicochemical Properties

M.Wt 511.59
Formula C28H32F3N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-((2S,5R)-2,5-diethyl-4-((S)-1-(4-(trifluoromethyl)phenyl)propyl)piperazin-1-yl)-1-methyl-2-oxo-1,2-dihydroquinazoline-6-carbonitrile

References

1. Wichroski M, et al. Cancer Immunol Res. 2025 Jun 12. doi: 10.1158/2326-6066.CIR-25-0156.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: