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VX-661

Chemical Structure : VX-661

CAS No.: 1152311-62-0

VX-661 (Tezacaftor)

Catalog No.: PC-20491Not For Human Use, Lab Use Only.

Tezacaftor (VX-661) is a broad-acting CFTR corrector that facilitates the cellular processing and trafficking of normal CFTR and multiple mutant CFTR forms, including F508del, thereby increasing the amount of CFTR protein at the cell surface, resulting in increased chloride transport.

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5 mg $98 In stock
10 mg $148 In stock
25 mg $258 In stock
50 mg $398 In stock
100 mg $588 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tezacaftor (VX-661) is a broad-acting CFTR corrector that facilitates the cellular processing and trafficking of normal CFTR and multiple mutant CFTR forms, including F508del, thereby increasing the amount of CFTR protein at the cell surface, resulting in increased chloride transport.

Physicochemical Properties

M.Wt 520.51
Formula C26H27F3N2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide

References

1. Scott H Donaldson, et al. Am J Respir Crit Care Med. 2018 Jan 15;197(2):214-224.

2. Veit G, et al. Sci Transl Med. 2014 Jul 23;6(246):246ra97.

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