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Chemical Structure : VX-661
CAS No.: 1152311-62-0
Catalog No.: PC-20491Not For Human Use, Lab Use Only.
Tezacaftor (VX-661) is a broad-acting CFTR corrector that facilitates the cellular processing and trafficking of normal CFTR and multiple mutant CFTR forms, including F508del, thereby increasing the amount of CFTR protein at the cell surface, resulting in increased chloride transport.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $588 | In stock | |
| 250 mg | Get quote |
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Tezacaftor (VX-661) is a broad-acting CFTR corrector that facilitates the cellular processing and trafficking of normal CFTR and multiple mutant CFTR forms, including F508del, thereby increasing the amount of CFTR protein at the cell surface, resulting in increased chloride transport.
| M.Wt | 520.51 | |
| Formula | C26H27F3N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropane-1-carboxamide |
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1. Scott H Donaldson, et al. Am J Respir Crit Care Med. 2018 Jan 15;197(2):214-224.
2. Veit G, et al. Sci Transl Med. 2014 Jul 23;6(246):246ra97.
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