ABBV-3221 | CFTR corrector | Probechem Biochemicals

Chemical Structure : ABBV-3221

Catalog No.: PC-38707Not For Human Use, Lab Use Only.

ABBV-3221 (GLPG-3221) is a highly potent CFTR corrector with HBE-TECC EC50 of 105 nM.

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Biological Activity

ABBV-3221 (GLPG-3221) is a highly potent CFTR corrector with HBE-TECC EC50 of 105 nM.

M.Wt	578.629
Formula	C30H37F3N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4S,5S)-3-(tert-butyl)-4-((2-methoxy-5-(trifluoromethyl)pyridin-3-yl)methoxy)-1-((S)-tetrahydro-2H-pyran-2-carbonyl)-5-(o-tolyl)pyrrolidine-2-carboxylic acid

1. Wang X, et al. J Med Chem. 2018 Feb 22;61(4):1436-1449.

2. Scanio MJC, et al. ACS Med Chem Lett. 2019 Oct 31;10(11):1543-1548.