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ABBV-3221

Chemical Structure : ABBV-3221

CAS No.: 2222264-64-2

ABBV-3221 (GLPG-3221)

Catalog No.: PC-38707Not For Human Use, Lab Use Only.

ABBV-3221 (GLPG-3221) is a highly potent CFTR corrector with HBE-TECC EC50 of 105 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ABBV-3221 (GLPG-3221) is a highly potent CFTR corrector with HBE-TECC EC50 of 105 nM.

    Physicochemical Properties

    M.Wt 578.629
    Formula C30H37F3N2O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2S,3R,4S,5S)-3-(tert-butyl)-4-((2-methoxy-5-(trifluoromethyl)pyridin-3-yl)methoxy)-1-((S)-tetrahydro-2H-pyran-2-carbonyl)-5-(o-tolyl)pyrrolidine-2-carboxylic acid

    References

    1. Wang X, et al. J Med Chem. 2018 Feb 22;61(4):1436-1449.

    2. Scanio MJC, et al. ACS Med Chem Lett. 2019 Oct 31;10(11):1543-1548.

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