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ARN23765

Chemical Structure : ARN23765

CAS No.: 2244458-40-8

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ARN23765 (ARN 23765)

Catalog No.: PC-38208Not For Human Use, Lab Use Only.

ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ARN23765 (ARN 23765) is a highly potent, pharmacological corrector of the mutant CFTR chloride channel with EC50 of 38 pM in cellular assays.
    ARN23765 is more than 5000-fold lower compared to presently available corrector drugs.
    ARN23765 also showed high efficacy, synergy with other types of correctors, and compatibility with chronic VX-770 potentiator.

    Physicochemical Properties

    M.Wt 615.513
    Formula C30H22F5N3O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-((1-(3-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)(methyl)carbamoyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-7-yl)oxy)benzoic acid

    References

    1. Nicoletta Pedemonte, et al. Sci Adv. 2020 Feb 21;6(8):eaay9669.

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