GLPG1837 | CFTR potentiator | Probechem Biochemicals

Chemical Structure : GLPG1837

CAS No.: 1654725-02-6

GLPG1837 (GLPG-1837, ABBV-974, ABBV974)

Catalog No.: PC-60232Not For Human Use, Lab Use Only.

GLPG1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
50 mg	$328	In stock
100 mg	$528	In stock
250 mg		Get quote

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Biological Activity

GLPG1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively.
GLPG1837 (ABBV-974) shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor.

Physicochemical Properties

M.Wt	348.421
Formula	C16H20N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-5-carboxamide

References

1. Van der Plas SE, et al. J Med Chem. 2017 Nov 17. doi: 10.1021/acs.jmedchem.7b01288.

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GLPG1837 (GLPG-1837, ABBV-974, ABBV974)

Biological Activity

Physicochemical Properties

References

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