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GLPG1837

Chemical Structure : GLPG1837

CAS No.: 1654725-02-6

GLPG1837 (GLPG-1837, ABBV-974, ABBV974)

Catalog No.: PC-60232Not For Human Use, Lab Use Only.

GLPG1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $198 In stock
50 mg $328 In stock
100 mg $528 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GLPG1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively.
GLPG1837 (ABBV-974) shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor.

Physicochemical Properties

M.Wt 348.421
Formula C16H20N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-5-carboxamide

References

1. Van der Plas SE, et al. J Med Chem. 2017 Nov 17. doi: 10.1021/acs.jmedchem.7b01288.

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