You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-CFTR-BPO-27 racemate
BPO-27 racemate

Chemical Structure : BPO-27 racemate

CAS No.: 1314873-02-3

BPO-27 racemate (BPO-27, BPO27)

Catalog No.: PC-45712Not For Human Use, Lab Use Only.

BPO-27 is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM).

Packing Price Stock Quantity
5 mg $248 In stock
10 mg $398 In stock
25 mg $598 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BPO-27 racemate is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM).
BPO-27 racemate shows improved potency, metabolic stability, and aqueous solubility compared to PPQ-102.
BPO-27 racemate prevents cyst growth with IC50 of 100 nM in embryonic kidney culture model of PKD.

Physicochemical Properties

M.Wt 548.34162
Formula C26H18BrN3O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6 mg/mL

Chemical Name/SMILES

6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-, (6R)-

References

1. Snyder DS, et al. J Med Chem. 2011 Aug 11;54(15):5468-77.

2. Snyder DS, et al. ACS Med Chem Lett. 2013 May 9;4(5):456-459.

3. Kim Y, et al. Mol Pharmacol. 2015 Oct;88(4):689-96.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: