Chemical Structure : BPO-27 racemate
CAS No.:
1314873-02-3
BPO-27 racemate
(BPO-27, BPO27)
Catalog No. : PC-45712Not For Human Use, Lab Use Only.
BPO-27 is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM).
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4571201
Biological Activity
BPO-27 racemate is a potent, metabolically stable CFTR inhibitor (IC50= 8 nM).
Physicochemical Properties
M.Wt
548.34162
Formula
C26H18BrN3O6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 6 mg/mL
Chemical Name/SMILES
6H-Pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, 6-(5-bromo-2-furanyl)-7,8,9,10-tetrahydro-7,9-dimethyl-8,10-dioxo-11-phenyl-, (6R)-
References
1. Snyder DS, et al. J Med Chem. 2011 Aug 11;54(15):5468-77.
2. Snyder DS, et al. ACS Med Chem Lett. 2013 May 9;4(5):456-459.
3. Kim Y, et al. Mol Pharmacol. 2015 Oct;88(4):689-96.
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