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Chemical Structure : KM11060
CAS No.: 774549-97-2
Catalog No.: PC-45770Not For Human Use, Lab Use Only.
KM11060 is a potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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KM11060 is a potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h).
KM11060 also can significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice.
| M.Wt | 422.3282 | |
| Formula | C19H17Cl2N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]- |
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1. Robert R, et al. Mol Pharmacol. 2008 Feb;73(2):478-89.
2. Loo TW, et al. Biochem Pharmacol. 2012 Feb 1;83(3):345-54.
3. Wu H, et al. PLoS One. 2014 Mar 26;9(3):e93003.
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