You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-CFTR-KM11060
KM11060

Chemical Structure : KM11060

CAS No.: 774549-97-2

KM11060 (KM 11060, KM-11060)

Catalog No.: PC-45770Not For Human Use, Lab Use Only.

KM11060 is a potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h).

Packing Price Stock Quantity
25 mg $118 In stock
50 mg $188 In stock
100 mg $298 In stock
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KM11060 is a potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h).
KM11060 also can significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice.

Physicochemical Properties

M.Wt 422.3282
Formula C19H17Cl2N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-

References

1. Robert R, et al. Mol Pharmacol. 2008 Feb;73(2):478-89.

2. Loo TW, et al. Biochem Pharmacol. 2012 Feb 1;83(3):345-54.

3. Wu H, et al. PLoS One. 2014 Mar 26;9(3):e93003.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: