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Chemical Structure : GLPG-2222
CAS No.: 1918143-53-9
Catalog No.: PC-60231Not For Human Use, Lab Use Only.
GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $228 | In stock | |
| 5 mg | $428 | In stock | |
| 10 mg | $728 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM.
GLPG-2222 is highly potent (5 nM) and efficacious in cells from multiple CF patient donors that have F508del homozygous mutation.
GLPG-2222 shows potential in clinical trials in patients harboring the F508del CFTR mutation on at least one allele.
| M.Wt | 559.47 | |
| Formula | C28H21F4NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[(2R,4R)-4-({[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic acid |
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1. Wang X, et al. J Med Chem. 2017 Dec 18. doi: 10.1021/acs.jmedchem.7b01339.
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