| Cat. No. |
Product Name |
Information |
| PC-26930 |
Cryptotanshinone
STAT3 inhibitor
|
Cryptotanshinone (CP1, Cryptotanshinon) is a potent STAT3 inhibitor with IC50 of 4.6 uM, inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells through blocking the dimerization of STAT3. |
| PC-26927 |
Astaxanthin
STAT3 inhibitor
|
Astaxanthin (AST) is a potent xanthophyll carotenoid with anti-tumor activity and antioxidant properties, targeting JAK2/STAT3/mTOR/PI3K pathways in gastric cancer (GC), exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. |
| PC-26783 |
HCB-5018
STAT3 inhibitor
|
HCB-5018 is a selective small molecule STAT3 inhibitor. |
| PC-26626 |
WB518
STAT3 inhibitor
|
WB518 is a specific small molecule STAT3 inhibitor, inhibits the phosphorylation of STAT3 Tyr705 (Y705). |
| PC-26586 |
STAT3-IN-12
STAT3 inhibitor
|
STAT3-IN-12 is a potent. selective STAT3 inhibitor, inhibits IL-6 induced JAK/STAT3 signalling pathway activation, inhibits cancer cell growth, migration, and induces cell apoptosis as well as cycle arrest. |
| PC-26446 |
ISS610
STAT3 inhibitor
|
ISS610 (ISS-610) is a selective peptidomimetic inhibitor of STAT3 dimerization with IC50 of 42 uM for STAT-DNA binding disruption, interacts with SH2 domain of STAT3 and shows 7.4-fold selective over STAT1. |
| PC-26387 |
Magnesium isoglycyrrhizinate hydrate
STAT3 inhibitor
|
Magnesium isoglycyrrhizinate (MgIG) is a stereoisomer of glycyrrhizic acid with more potent hepatoprotective activity and less side effects than glycyrrhizic acid, inhibits inflammatory response through STAT3 pathway, also inhibits the activation of the LPS/TLRs/NF-κB signaling pathway in liver injury caused by anti-tuberculosis (anti-TB) drugs. |
| PC-26209 |
WP-1034
JAK-STAT inhibitor
|
WP-1034 is a small molecule JAK-STAT inhibitor, blocks Stat3 and Stat5 and induces caspase-dependent apoptosis in acute myeloid leukemia (AML). |
| PC-26022 |
WR-S-647
STAT3 inhibitor
|
WR-S-647 is a potent and specific inhibitor of STAT3 with binding affinity (SPR Kd) of 34 nM. |
| PC-25692 |
STAT6 ligand-1
STAT6 ligand
|
STAT6 ligand-1 is a specific ligand of STAT6 used for synthesizing STAT6 PROTAC degraders. |
| PC-25690 |
STAT6-IN-9
STAT6 inhibitor
|
STAT6-IN-9 is a potent, selective STAT6 inhibitor with EC50 of 4 nM, efficiently blocks the STAT6 activation process mediated by the IL-13-IL-13 receptor/IL-4 receptor pathway, potently inhibits CCL17 secretion with IC50 of 4.6 nM. |
| PC-25689 |
STAT6-IN-7
STAT6 inhibitor
|
STAT6-IN-7 is a potent, selective STAT6 inhibitor with IC50 of 0.28 uM in STAT6 reporter assay using STAT6-HEK293 cells. |
