| Cat. No. |
Product Name |
Information |
| PC-60456 |
Cucurbitacin I
JAK/STAT3 inhibitor
|
Cucurbitacin I (JSI-124) is a triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM. |
| PC-60417 |
Debio 0617B
Multi-kinases inhibitor
|
Debio 0617B is a first-in-class, multi-kinase inhibitor that targets pSTAT3 and/or pSTAT5 in cancer cells through combined inhibition of JAK, SRC, ABL, and class III/V RTKs (Kd<100 nM). |
| PC-42174 |
BP-1-102
STAT3 inhibitor
|
BP-1-102 is an orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM. |
| PC-42160 |
HO-3867
STAT3 inhibitor
|
HO-3867 is a synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. |
| PC-42175 |
SH5-07
STAT3 inhibitor
|
SH5-07 (SH-5-07, SH 5-07) is a potent, selective small-molecule STAT3 inhibitor with IC50 of 3.9 uM. |
| PC-45109 |
SH-4-54
STAT3 inhibitor
|
SH-4-54 is a potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM. |
| PC-43790 |
Napabucasin
STAT3 inhibitor
|
Napabucasin (BBI608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM). |
| PC-42210 |
AS1517499
STAT6 inhibitor
|
AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay. |
| PC-28252 |
STAT3 CCD inhibitor K134
STAT3 inhibitor
|
K134 is a specific STAT3 coiled-coil domain (CCD) inhibitor with binding Kd of 4.68 uM, attenuates LPS-induced acute lung injury (ALI) inflammation by targeting STAT3 phosphorylation. |
| PC-28221 |
ISS840
STAT1 inhibitor
|
ISS840 is a isoform-selective, peptidomimetic inhibitor of STAT1 homo-dimerization with IC50 of 31 uM, >15-fold selectivity over STAT3. |
| PC-28219 |
FLLL11
STAT3 inhibitor
|
FLLL11 is a curcumin analogue and STAT3 inhibitor, effectively inhibits STAT3, AKT, and HER2/neu pathways, inhibits STAT3 DNA binding and STAT3 transcriptional activity |
| PC-28218 |
FLLL12
STAT3 inhibitor
|
FLLL12 is a curcumin analogue and STAT3 inhibitor, effectively inhibits STAT3, AKT, and HER2/neu pathways, inhibits STAT3 DNA binding and STAT3 transcriptional activity |
