| Cat. No. |
Product Name |
Information |
| PC-47050 |
LLL12B
STAT3 inhibitor
|
LLL12B is a selective STAT3 inhibitor that suppresses Th17 development, specifically inhibits STAT3 and suppresses Th17 differentiation and expansion. |
| PC-38849 |
W1131
STAT3 inhibitor
|
W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo. |
| PC-38756 |
pan-IFN inhibitor 5k
JAK-STAT inhibitor
|
pan-IFN inhibitor 5k is a potent and selective inhibitor of interferon-induced JAK-STAT signalling, blocks IFNγ activation of JAK-STAT signalling, also inhibits type I and III IFN-induced STAT phosphorylation in vitro. |
| PC-73189 |
WP1066
STAT3 inhibitor
|
WP1066 is a potent, cell-active STAT3 pathway inhibitor, inhibits human malignant glioma U87-MG and U373-MG cells in vitro with IC50 of 5.6 and 3.7 uM. |
| PC-73110 |
SI-109
STAT3 inhibitor
|
SI-109 (SI 109) is a selective, high-affinity and cell-permeable STAT3 SH2 domain inhibitor with Ki of 9 nM, component of STAT3 degrader SD-36 (PROTAC). |
| PC-72849 |
SS-4
STAT3 inhibitor
|
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo. |
| PC-72002 |
Stat3 inhibitor H182
STAT3 inhibitor
|
Stat3 inhibitor H182 is a potent, selective STAT3 inhibitor, inhibits Stat3 DNA-binding activity with IC50 of 0.66 uM. |
| PC-38322 |
Stafia-1 prodrug
STAT5a inhibitor
|
Stafia-1 prodrug is the cell-permeable prodrug of Stafia-1 (Cat. PC-38321), and is suitable for cell based assays, inhibits tyrosine phosphorylation of STAT5a with selectivity over STAT5b in cultured human leukemia cells. |
| PC-38321 |
Stafia-1
STAT5a inhibitor
|
Stafia-1 is a selective inhibitor of STAT5a with Ki of 10.9 uM, preferentially inhibits STAT5a over the close homologue STAT5b (>9-fold) and other STAT family member. |
| PC-35089 |
PM-43I
STAT5/6 inhibitor
|
PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM). |
| PC-63206 |
KI16
STAT3 inhibitor
|
KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain. |
| PC-63164 |
TRi-1
TXNRD1 inhibitor
|
TRi-1 (TXNRD1 inhibitor 1) is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1) with anticancer potential, 5- to 10-fold higher specificity for TXNRD1 over TXNRD2. |
