| Cat. No. |
Product Name |
Information |
| PC-20635 |
MNS1-MV
STAT3 inhibitor
|
MNS1-MV is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
| PC-20634 |
IST5-002
Stat5 inhibitor
|
IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells. |
| PC-20632 |
STAT3 inhibitor LY5
STAT3 inhibitor
|
STAT3 inhibitor LY5 is a specfic STAT3 small molecule inhibitor, binds to STAT3 SH2 domain wioth Kd of 2.5 uM. |
| PC-20631 |
BP-1-108
STAT5 inhibitor
|
BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively). |
| PC-20627 |
W2014-S
STAT3 inhibitor
|
W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling. |
| PC-20605 |
STAT3 inhibitor DG-4
TrxR1 inhibitor
|
DG-4 is a potent, selective inhibitor of STAT3-dependent transcription with IC50 of 0.12 uM in IL6-STAT3 luciferase reporter assays, 44-fold selectivity over IFN-γ STAT1. |
| PC-20465 |
S3I-201
STAT3 inhibitor
|
S3I-201 (NSC74859, S31-201) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM. |
| PC-20357 |
HP590
STAT3 inhibitor
|
HP590 is a highly potent, and orally bioavailable STAT3 inhibitor with IC50 of 27.8 nM, inibits IL-6 induced of the p-STAT3 Tyr705 and p-Ser727 activation in GC cells with lower nanomolar inhibitory activity. |
| PC-20120 |
K1836
STAT3 inhibitor
|
K1836 is a small molecule Stattic analog inhibitor of STAT3 signalling, blocks STAT3 phosphorylation. |
| PC-20066 |
W1046
STAT3 inhibitor
|
W1046 is a potent and selective STAT3 inhibitor, decreases the expression of VISTA at mRNA and protein level and inhibits proliferation and survival in AML cells. |
| PC-49781 |
MC0704
STAT3 inhibitor
|
MC0704 (MC-0704) is a novel synthetic STAT3 pathway inhibitor with IC50 of 2.13 uM. |
| PC-49596 |
SOST inhibitor S6
Sclerostin inhibitor
|
SOST inhibitor S6 is a small-molecule targeting Sclerostin (SOST), blocks STAT3 binding to SOST, inhibits breast cancer bone metastasis. |
