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KI16

Chemical Structure : KI16

CAS No.: 1090696-43-7

KI16 (STAT3 inhibitor KI16)

Catalog No.: PC-63206Not For Human Use, Lab Use Only.

KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain.

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    Biological Activity

    KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain.
    KI16 inhibits STAT3 phosphorylation and transcriptional activity in response to IL6 stimulation.
    KI16 inhibits cell viability preferentially in STAT3-dependent cell lines.

    Physicochemical Properties

    M.Wt 328.302
    Formula C14H8N4O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-nitro-2-((3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)thio)nicotinonitrile

    References

    1. Kolosenko I, et al. PLoS One. 2017 Jun 21;12(6):e0178844.

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