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PM-43I

Chemical Structure : PM-43I

CAS No.: 1637532-77-4

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PM-43I (PM-43-I)

Catalog No.: PC-35089Not For Human Use, Lab Use Only.

PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM).
    PM-43I potently inhibits both STAT5- and STAT6-dependent allergic airway disease in mice.
    PM-43I reverses preexisting allergic airway disease in mice with a minimum ED50 of 0.25 μg/kg.

    Physicochemical Properties

    M.Wt 777.8
    Formula C38H50F2N3O10P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S,E)-(((Difluoro(4-(4-((1-(2-(methyl(phenyl)amino)-2-oxoethyl)-2-oxoazepan-3-yl)amino)-4-oxobut-2-en-2-yl)phenyl)methyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

    References

    1. Knight JM, et al. J Biol Chem. 2018 May 8. pii: jbc.RA117.000567.

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