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Chemical Structure : PM-43I
Catalog No.: PC-35089Not For Human Use, Lab Use Only.
PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM).
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PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM).
PM-43I potently inhibits both STAT5- and STAT6-dependent allergic airway disease in mice.
PM-43I reverses preexisting allergic airway disease in mice with a minimum ED50 of 0.25 μg/kg.
| M.Wt | 777.8 | |
| Formula | C38H50F2N3O10P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Knight JM, et al. J Biol Chem. 2018 May 8. pii: jbc.RA117.000567.
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