| Cat. No. |
Product Name |
Information |
| PC-49462 |
WB436B
STAT3 inhibitor
|
WB436B is a potent and highly selective small molecule inhibitor of STAT3, specifically targets the STAT3-SH2 domain with KD value of 94.3 nM. |
| PC-49434 |
DR-1-55
STAT3 inhibitor
|
DR-1-55 (DR-155) is a selective STAT3 inhibitor that covalently modifies a cysteine in the SH2 domain of STAT3. |
| PC-49156 |
KS10076
STAT3 inhibitor, Metal chelator
|
KS10076 is a metal chelator with potent anti-cancer cytotoxicity, destabilizes STAT3 by elevating ROS, shows remarkable cytotoxic efficacy in 100 cancer cell lines of different types with IC50 of <1 uM. |
| PC-49088 |
STX-0119
STAT3 inhibitor
|
STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM. |
| PC-47064 |
ODZ10117
STAT3 inhibitor
|
ODZ10117 is a small molecule inhibitor of STAT3, effectively inhibits the level of tyrosine phosphorylated STAT3 in various cancer cell lines. |
| PC-47050 |
LLL12B
STAT3 inhibitor
|
LLL12B is a selective STAT3 inhibitor that suppresses Th17 development, specifically inhibits STAT3 and suppresses Th17 differentiation and expansion. |
| PC-38849 |
W1131
STAT3 inhibitor
|
W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo. |
| PC-38756 |
pan-IFN inhibitor 5k
JAK-STAT inhibitor
|
pan-IFN inhibitor 5k is a potent and selective inhibitor of interferon-induced JAK-STAT signalling, blocks IFNγ activation of JAK-STAT signalling, also inhibits type I and III IFN-induced STAT phosphorylation in vitro. |
| PC-38627 |
STAT3 inhibitor N4
STAT3 inhibitor
|
STAT3 inhibitor N4 is a small molecule capable of inhibiting the STAT3 SH2 domain with IC50 of 0.57 uM, SPR KD of 1.04 uM, inhibits STAT3 dimerization and transcription in vitro and suppresses pancreatic cancer in vivo. |
| PC-73189 |
WP1066
STAT3 inhibitor
|
WP1066 is a potent, cell-active STAT3 pathway inhibitor, inhibits human malignant glioma U87-MG and U373-MG cells in vitro with IC50 of 5.6 and 3.7 uM. |
| PC-73110 |
SI-109
STAT3 inhibitor
|
SI-109 (SI 109) is a selective, high-affinity and cell-permeable STAT3 SH2 domain inhibitor with Ki of 9 nM, component of STAT3 degrader SD-36 (PROTAC). |
| PC-72849 |
SS-4
STAT3 inhibitor
|
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo. |
