| Cat. No. |
Product Name |
Information |
| PC-62863 |
NSC 368262
STAT3 inhibitor
|
NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers. |
| PC-62732 |
ML115
STAT3 agonist
|
ML115 is a potent, selective STAT3 agonist with EC50 of 2.0 nM, inactive against the related STAT1, STAT5 and NF-κB anti-targets. |
| PC-62576 |
QD 232
STAT3 inhibitor
|
QD 232 is a novel quinazolinedione-based redox modulator that potently inhibits Src/FAK and STAT3 phosphorylation, decreasing pancreatic cancer cell viability and migration. |
| PC-62556 |
AC-4-130
STAT5 inhibitor
|
AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. |
| PC-62521 |
NSC 311068
STAT3/5 inhibitor
|
NSC 311068 is a small molecule that directly tragets and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
| PC-62520 |
NSC 370284
STAT3/5 inhibitor
|
NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
| PC-62519 |
UC-514321
STAT3/5 inhibitor, TET1 inhibitor
|
UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
| PC-62444 |
Pimozide
STAT5 inhibitor, USP1 inhibitor
|
Pimozide (R6238) is an antipsychotic agent that acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor, also is an inhbitor of STAT5. |
| PC-62432 |
Hydrazinocurcumin
STAT3 inhibitor
|
Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets. |
| PC-62378 |
InS3-54
STAT3 inhibitor
|
InS3-54 is a small molecule STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3. |
| PC-62377 |
InS3-54A18
STAT3 inhibitor
|
InS3-54A18 is an active analog of inS3-54 targeting the DBD of STAT3 with IC50 of 8.8 uM in STAT3-dependent luciferase reporter assay, with increased specificity and pharmacological properties. |
| PC-62347 |
S3I-M2001
STAT3 inhibitor
|
S3I-M2001 (Bromohydroxyacetone phosphate) is an oxazole-based peptidomimetic of the STAT3 SH2 domain-binding phosphotyrosine peptide that selectively disrupts active STAT3:STAT3 dimers. |
