Catalog No.: PC-49088Not For Human Use, Lab Use Only.
STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM.
STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM.
STX-0119 selectively abrogates the DNA binding activity of STAT3 and suppressed the expression of STAT3-regulated oncoproteins such as c-myc and survivin in cancer cells.
STX-0119 (160 mg/kg sid, p.o.) effectively abrogated the growth of human lymphoma cells in a SCC-3 subcutaneous xenograft model without visible toxicity.
STX-0119 attenuates liver fibrosis by inactivating hepatic stellate cells in mice.
