Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : STX-0119
CAS No.: 851095-32-4
Catalog No.: PC-49088Not For Human Use, Lab Use Only.
STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM.
STX-0119 selectively abrogates the DNA binding activity of STAT3 and suppressed the expression of STAT3-regulated oncoproteins such as c-myc and survivin in cancer cells.
STX-0119 (160 mg/kg sid, p.o.) effectively abrogated the growth of human lymphoma cells in a SCC-3 subcutaneous xenograft model without visible toxicity.
STX-0119 attenuates liver fibrosis by inactivating hepatic stellate cells in mice.
| M.Wt | 382.37 | |
| Formula | C22H14N4O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide |
|
1. Matsuno K, et al. ACS Med Chem Lett. 2010 Jul 13;1(8):371-5.
2. Ashizawa T, et al. Int J Oncol. 2013 Jul;43(1):219-27.
3. Choi S, et al. Biochem Biophys Res Commun. 2019 May 21;513(1):49-55.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
