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Chemical Structure : W1131
Catalog No.: PC-38849Not For Human Use, Lab Use Only.
W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo.
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W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo.
W1131 inhibited STAT3 tyrosine phosphorylation and dimerization, accumulation of nuclear pY705-STAT3, and transcriptional activity.
W1131 inhibited STAT3 Tyr705 phosphorylation in a time- and dose-dependent manner without obvious effect on the activation of STAT1 and STAT5, W1131 had no obvious effect on phospho-JAK2 or phospho-AKT levels.
W1131 strongly inhibited cell survival, migration, and invasion, W1131 (1 uM) triggers ferroptosis and inhibited GPX4, SLC7A11, and FTH1 expression in gastric cancer cells.
W1131 (3 mg/kg and 10 mg/kg, i.p.) induced ferroptosis and regressed tumor growth of gastric cancer in vivo.
W1131 also alleviated chemotherapy resistance (5-FU) in multiple models of gastric cancer.
| M.Wt | 429.436 | |
| Formula | C23H19N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ouyang S, et al. Redox Biol. 2022 Jun;52:102317.
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