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Chemical Structure : KS10076
Catalog No.: PC-49156Not For Human Use, Lab Use Only.
KS10076 is a metal chelator with potent anti-cancer cytotoxicity, destabilizes STAT3 by elevating ROS, shows remarkable cytotoxic efficacy in 100 cancer cell lines of different types with IC50 of <1 uM.
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KS10076 is a metal chelator with potent anti-cancer cytotoxicity, destabilizes STAT3 by elevating ROS, shows remarkable cytotoxic efficacy in 100 cancer cell lines of different types with IC50 of <1 uM.
KS10076 induces STAT3 degradation and thereby promotes autophagic cell death via the EIF2A/LC3B signaling pathway.
KS10076 eliminates pSTAT3/ALDH1+ stem cells in CRC patient-derived organoids.
KS10076 significantly reduced STAT3 and ALDH1 in HCT116 and SW480 murine xenograft models.
| M.Wt | 379.497 | |
| Formula | C16H21N5O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jaehee Kim, et al. Cell Rep. 2022 Jul 19;40(3):111077.
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