| Cat. No. |
Product Name |
Information |
| PC-23511 |
HJC0416 hydrochloride
STAT3 inhibitor
|
HJC0416 hydrochloride is an orally bioavailable small-molecule STAT3 inhibitor, decreases the STAT3 promoter activity in MDA-MB-231 cells with IC50 of 5 uM. |
| PC-23197 |
Scutellarin
STAT3 inhibitor
|
Scutellarin is an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, also shows anti-HIV-1 activity. |
| PC-23177 |
AK-068
STAT6 inhibitor
|
AK-068 is a highly potent, selective STAT6 ligand / inhibitor with Ki of 6 nM, binds to STAT6 SH2 domain. |
| PC-23165 |
K2071
STAT3 inhibitor
|
K2071 is a potent, BBB penetrant STAT3 inhibitor, inhibits IL6-stimulated activity of STAT3 mediated byTyr705 phosphorylation, shows cytotoxicity against a set of human glioblastoma-derived cell lines. |
| PC-22095 |
YY002
STAT3 inhibitor
|
YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation. |
| PC-21874 |
WZ-2-033
STAT3 inhibitor
|
WZ-2-033 is a potent, selective STAT3 inhibitor, binds to the SH2 domain of the STAT3 protein with KD of 7.4 uM, disrupts STAT3 dimerization and significantly inhibits STAT3 signaling. |
| PC-20636 |
MNS1-Leu
STAT3 inhibitor
|
MNS1-Leu is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
| PC-20635 |
MNS1-MV
STAT3 inhibitor
|
MNS1-MV is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
| PC-20633 |
TR120
STAT5 inhibitor
|
TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells. |
| PC-20632 |
STAT3 inhibitor LY5
STAT3 inhibitor
|
STAT3 inhibitor LY5 is a specfic STAT3 small molecule inhibitor, binds to STAT3 SH2 domain wioth Kd of 2.5 uM. |
| PC-20631 |
BP-1-108
STAT5 inhibitor
|
BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively). |
| PC-20630 |
SF-1-088
STAT5 inhibitor
|
SF-1-088 is a small molecule STAT5-SH2 domain inhibitor with Ki of 8.3 uM (Stat5b), shows no affinity for Stat1 and Stat3 (Ki>25 uM). |
