| Cat. No. |
Product Name |
Information |
| PC-43790 |
Napabucasin
STAT3 inhibitor
|
Napabucasin (BBI608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM). |
| PC-42210 |
AS1517499
STAT6 inhibitor
|
AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay. |
| PC-25257 |
WR-S-462
STAT3 inhibitor
|
WR-S-462 is a highly potent and selective STAT3 inhibitor with SPR Kd of 58 nM, directly interferes with the STAT3-SH2 domain interaction. |
| PC-25251 |
LZJ66
STAT3 inhibitor
|
LZJ66 (STAT3-IN-20, Compound 40) is a potent, selective STAT3 inhibitor, inhibits L-6/JAK/STAT3 signaling pathway with IC50 of 0.65 uM. |
| PC-25250 |
STAT3 inhibitor W36
STAT3 inhibitor
|
STAT3 inhibitor W36 is a potent, selective STAT3 inhibitor with SPR KD of 323.3 nM, inhibits IL-6/JAK/STAT3 signaling pathway with IC50 of 0.87 uM in HEK-Blue-IL-6 cell model. |
| PC-24939 |
STAT3 inhibitor YZ-35
STAT3 inhibitor
|
STAT3 inhibitor YZ-35 is potent, selective STAT3 inhibitor with binding Kd of 190 nM in ITC assays amd Ki of 380 nM in FP assays. |
| PC-24861 |
STAT6-IN-5
STAT6 inhibitor
|
STAT6-IN-5 (compound 84) is a potent, selective STAT6 inhibitor with IC50 of 0.24 uM, compound 84 extracted from patent WO2024071439 A1. |
| PC-24860 |
STAT6-IN-6
STAT6 inhibitor
|
STAT6-IN-6 is a potent, selective STAT6 inhibitor. |
| PC-24794 |
STAT6-IN-4
STAT6 inhibitor
|
STAT6-IN-4 (Example 78) is a potent, selective STAT6 inhibitor with IC50 of 0.34 uM, example 78 in patent WO2024071439 A1. |
| PC-24629 |
PMM-172
STAT3 inhibitor
|
PMM-172 is a specific small molecule STAT3 inhibitor targeting STAT3 SH2 domain, inhibits STAT3 downstream target genes expression, shows anti-proliferative activity against MDA-MB-231 cells with IC50 of 1.98 uM. |
| PC-24623 |
RDp002
STAT3 inhibitor
|
RDp002 is a potent novel small molecule STAT3 inhibitor, interacts with STAT3 SH2 domain with KD of 4.23 uM, inhibits STAT3 phosphorylation of STAT3 at tyrosine 705 and serine 727 residues. |
| PC-24431 |
STAT3 inhibitor K116
STAT3 inhibitor
|
K116 is a potent allosteric inhibitor specifically targeting the STAT3 coiled-coil domain (CCD), selectively inhibits the phosphorylation of p-Y705STAT3 in breast cancer cell lines. |
