| Cat. No. |
Product Name |
Information |
| PC-42174 |
BP-1-102
STAT3 inhibitor
|
BP-1-102 is an orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM. |
| PC-42160 |
HO-3867
STAT3 inhibitor
|
HO-3867 is a synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. |
| PC-42175 |
SH5-07
STAT3 inhibitor
|
SH5-07 (SH-5-07, SH 5-07) is a potent, selective small-molecule STAT3 inhibitor with IC50 of 3.9 uM. |
| PC-45109 |
SH-4-54
STAT3 inhibitor
|
SH-4-54 is a potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM. |
| PC-43790 |
Napabucasin
STAT3 inhibitor
|
Napabucasin (BBI608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM). |
| PC-42210 |
AS1517499
STAT6 inhibitor
|
AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay. |
| PC-26446 |
ISS610
STAT3 inhibitor
|
ISS610 (ISS-610) is a selective peptidomimetic inhibitor of STAT3 dimerization with IC50 of 42 uM for STAT-DNA binding disruption, interacts with SH2 domain of STAT3 and shows 7.4-fold selective over STAT1. |
| PC-26387 |
Magnesium isoglycyrrhizinate hydrate
STAT3 inhibitor
|
Magnesium isoglycyrrhizinate (MgIG) is a stereoisomer of glycyrrhizic acid with more potent hepatoprotective activity and less side effects than glycyrrhizic acid, inhibits inflammatory response through STAT3 pathway, also inhibits the activation of the LPS/TLRs/NF-κB signaling pathway in liver injury caused by anti-tuberculosis (anti-TB) drugs. |
| PC-26212 |
Pomstafib-2-CR
STAT5b inhibitor
|
Pomstafib-2-CR is the ester prodrug of Stafib-2-CR, which is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM. |
| PC-26211 |
Stafib-2-CR
STAT5b inhibitor
|
Stafib-2-CR is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM, shows 69-fold selectivity over STAT5a. |
| PC-26209 |
WP-1034
JAK-STAT inhibitor
|
WP-1034 is a small molecule JAK-STAT inhibitor, blocks Stat3 and Stat5 and induces caspase-dependent apoptosis in acute myeloid leukemia (AML). |
| PC-26022 |
WR-S-647
STAT3 inhibitor
|
WR-S-647 is a potent and specific inhibitor of STAT3 with binding affinity (SPR Kd) of 34 nM. |
