| Cat. No. |
Product Name |
Information |
| PC-24939 |
STAT3 inhibitor YZ-35
STAT3 inhibitor
|
STAT3 inhibitor YZ-35 is potent, selective STAT3 inhibitor with binding Kd of 190 nM in ITC assays amd Ki of 380 nM in FP assays. |
| PC-24861 |
STAT6-IN-5
STAT6 inhibitor
|
STAT6-IN-5 (compound 84) is a potent, selective STAT6 inhibitor with IC50 of 0.24 uM, compound 84 extracted from patent WO2024071439 A1. |
| PC-24860 |
STAT6-IN-6
STAT6 inhibitor
|
STAT6-IN-6 is a potent, selective STAT6 inhibitor. |
| PC-24794 |
STAT6-IN-4
STAT6 inhibitor
|
STAT6-IN-4 (Example 78) is a potent, selective STAT6 inhibitor with IC50 of 0.34 uM, example 78 in patent WO2024071439 A1. |
| PC-24629 |
PMM-172
STAT3 inhibitor
|
PMM-172 is a specific small molecule STAT3 inhibitor targeting STAT3 SH2 domain, inhibits STAT3 downstream target genes expression, shows anti-proliferative activity against MDA-MB-231 cells with IC50 of 1.98 uM. |
| PC-24625 |
LLY17
STAT3 inhibitor
|
LLY17 (Compound 9) is an orally available, potent, and selective STAT3, directly and selectively inhibited the pY705 site of STAT3 with Ki of 400 nM. |
| PC-24623 |
RDp002
STAT3 inhibitor
|
RDp002 is a potent novel small molecule STAT3 inhibitor, interacts with STAT3 SH2 domain with KD of 4.23 uM, inhibits STAT3 phosphorylation of STAT3 at tyrosine 705 and serine 727 residues. |
| PC-24431 |
STAT3 inhibitor K116
STAT3 inhibitor
|
K116 is a potent allosteric inhibitor specifically targeting the STAT3 coiled-coil domain (CCD), selectively inhibits the phosphorylation of p-Y705STAT3 in breast cancer cell lines. |
| PC-24308 |
Hygromycin B
CHI3L1-STAT3 inhibitor
|
Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells, also an inhibitor of the STAT3-CCD domain, disrupts the CHI3L1-STAT3 interaction, inhibits glioblastoma both in vitro and in vivo. |
| PC-24234 |
Stafori-1
STAT4 inhibitor
|
Stafori-1 is the first specific small-molecule inhibitor of STAT4, inhibits the protein-protein interaction domain of STAT4, the SH2 domain, with Ki of 1.7 uM, 10-70-fold selectivity over other STAT proteins. |
| PC-24072 |
Angoline
IL6/STAT3 inhibitor
|
Angoline is a potent and selective inhibitor of IL6/STAT3 signaling pathway with IC50 of 11.56 uM, inhibits STAT3 phosphorylation and its target gene expression, also is an inhibitor of MORC2 protein, significantly kills the TNBC cells by blocking cell cycle and inducing apoptosis. |
| PC-24045 |
STAT3 inhibitor NA16
STAT3 inhibitor
|
STAT3 inhibitor NA16 is a nifuroxazide analog and STAT3 inhibitor, downregulates FoxP3 expression with IC50 of 4.7 uM in TCR-stimulated total T cells. |
