| Cat. No. |
Product Name |
Information |
| PC-23197 |
Scutellarin
STAT3 inhibitor
|
Scutellarin is an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, also shows anti-HIV-1 activity. |
| PC-23177 |
AK-068
STAT6 inhibitor
|
AK-068 is a highly potent, selective STAT6 ligand / inhibitor with Ki of 6 nM, binds to STAT6 SH2 domain. |
| PC-23165 |
K2071
STAT3 inhibitor
|
K2071 is a potent, BBB penetrant STAT3 inhibitor, inhibits IL6-stimulated activity of STAT3 mediated byTyr705 phosphorylation, shows cytotoxicity against a set of human glioblastoma-derived cell lines. |
| PC-22095 |
YY002
STAT3 inhibitor
|
YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation. |
| PC-21874 |
WZ-2-033
STAT3 inhibitor
|
WZ-2-033 is a potent, selective STAT3 inhibitor, binds to the SH2 domain of the STAT3 protein with KD of 7.4 uM, disrupts STAT3 dimerization and significantly inhibits STAT3 signaling. |
| PC-20636 |
MNS1-Leu
STAT3 inhibitor
|
MNS1-Leu is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
| PC-20635 |
MNS1-MV
STAT3 inhibitor
|
MNS1-MV is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
| PC-20633 |
TR120
STAT5 inhibitor
|
TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells. |
| PC-20632 |
STAT3 inhibitor LY5
STAT3 inhibitor
|
STAT3 inhibitor LY5 is a specfic STAT3 small molecule inhibitor, binds to STAT3 SH2 domain wioth Kd of 2.5 uM. |
| PC-20631 |
BP-1-108
STAT5 inhibitor
|
BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively). |
| PC-20630 |
SF-1-088
STAT5 inhibitor
|
SF-1-088 is a small molecule STAT5-SH2 domain inhibitor with Ki of 8.3 uM (Stat5b), shows no affinity for Stat1 and Stat3 (Ki>25 uM). |
| PC-20629 |
SF-1-066
STAT3 inhibitor
|
SF-1-066 is an orally bioavailable inhibitor of STAT3 with IC50 of 35 uM for inhibition of STAT3 DNA binding activity in vitro, binds to the STAT3 SH2 domain and inhibits STAT3 dimerization. |
