Chemical Structure : PMM-172
CAS No.:
1844869-66-4
PMM-172
(PMM172)
Catalog No.: PC-24629Not For Human Use, Lab Use Only.
PMM-172 is a specific small molecule STAT3 inhibitor targeting STAT3 SH2 domain, inhibits STAT3 downstream target genes expression, shows anti-proliferative activity against MDA-MB-231 cells with IC50 of 1.98 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PMM-172 is a specific small molecule STAT3 inhibitor targeting STAT3 SH2 domain, inhibits STAT3 downstream target genes expression, shows anti-proliferative activity against MDA-MB-231 cells with IC50 of 1.98 uM.
PMM-172 induced apoptosis in MDA-MB-231 cells in dose- and time- dependent manners.
PMM-172 reduced mitochondrial transmembrane potential in MDA-MB-231 cells.
PMM-172 reduced constitutive pSTAT3 (Tyr705) and inducible STAT3 activation in MDA-MB-231 cells.
PMM-172 does not inhibits phosphorylation or expression of STAT1 and STAT5.
PMM-172 suppressed STAT3 nuclear localization, and inhibited STAT3 downstream target genes expression.
Physicochemical Properties
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M.Wt
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566.58
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Formula
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C28H26N2O9S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 2-((5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetate
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References
1. Han-Yue Qiu, et al. Sci Rep. 2017 Jun 6;7(1):2863.
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