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Chemical Structure : AS1517499
CAS No.: 919486-40-1
Catalog No.: PC-42210Not For Human Use, Lab Use Only.
AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $468 | In stock | |
| 100 mg | Get quote |
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AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.
AS1517499 inhibits IL-4-induced Th2 differentiation of mouse spleen T cells with IC50 of 2.3 nM, without influencing Th1 differentiation induced by IL-12.
AS1517499 completely inhibits both the antigen-induced up-regulation of RhoA and BSM hyperresponsiveness, significantly inhibits antigen-induced production of IL-13 in mice.
| M.Wt | 397.8581 | |
| Formula | C20H20ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
5-Pyrimidinecarboxamide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]- |
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1. Nagashima S, et al. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55.
2. Chiba Y, et al. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24.
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