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Chemical Structure : Napabucasin
CAS No.: 83280-65-3
Catalog No.: PC-43790Not For Human Use, Lab Use Only.
Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $168 | In stock | |
| 100 mg | $348 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
Napabucasin (BBI-608) blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells.
Napabucasin (BBI-608) significantly reduces the expression of various stemness genes, including Nanog, Sox2, and Oct4 (POU5F1).
Napabucasin (BBI-608) significantly inhibits PaCa-2 xenograft tumor growth, and inhibits cancer relapse and metastasis.
| M.Wt | 240.2109 | |
| Formula | C14H8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Naphtho[2,3-b]furan-4,9-dione, 2-acetyl- |
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1. Li Y, et al. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44.
2. Zhang Y, et al. Cancer Med. 2016 Jun;5(6):1251-8.
3. Hubbard JM, et al. Drugs. 2017 Jul;77(10):1091-1103.
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