Catalog No.: PC-43790Not For Human Use, Lab Use Only.
Napabucasin (BBI608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
Napabucasin (BBI608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
Napabucasin (BBI608) blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells.
Napabucasin (BBI608) significantly reduces the expression of various stemness genes, including Nanog, Sox2, and Oct4 (POU5F1).
Napabucasin (BBI608) significantly inhibits PaCa-2 xenograft tumor growth, and inhibits cancer relapse and metastasis.
Physicochemical Properties
M.Wt
240.2109
Formula
C14H8O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Naphtho[2,3-b]furan-4,9-dione, 2-acetyl-
References
1. Li Y, et al. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44.
2. Zhang Y, et al. Cancer Med. 2016 Jun;5(6):1251-8.
3. Hubbard JM, et al. Drugs. 2017 Jul;77(10):1091-1103.
